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从动物实验结果中,阿霉素和烷化剂联合应用,可以增加治疗效果。消瘤芥(AT-1258)为我国合成的一个烷化剂,对肺癌有一定疗效。本院自1981年3月～1982年12月以阿霉素和消瘤芥治疗的非雀麦细胞肺癌22例,并和单用消瘤芥的19例作为对照,来评价疗效。 病员选择:经组织学或细胞学证实的非雀麦细胞肺癌;年龄在30～65岁间;全身情况大于Karnofsky performance status60分;属于1978年UICC肺癌分期中Ⅲ期、转移达锁骨上淋巴结
From the results of animal experiments, the combination of doxorubicin and alkylating agents can increase the therapeutic effect. The tumor-killing mustard (AT-1258) is an alkylating agent synthesized in China and has a certain effect on lung cancer. In our hospital, from March 1981 to December 1982, 22 cases of non-BLL lung cancer treated with doxorubicin and anti-tumor mustard were used, and 19 cases were treated with anti-cancer alone as a control to evaluate the efficacy. Patient selection: Non-Brygar cell lung cancer confirmed by histology or cytology; aged between 30 and 65; systemic condition greater than Karnofsky performance status 60 points; belongs to stage III of 1978 UICC lung cancer staging, metastasis to supraclavicular lymph node