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目的:分析某院2012年至2015年头孢他啶使用与临床分离的6种主要革兰阴性细菌耐药之间的相关性,为该类抗菌药物的合理应用提供理论依据。方法:从医院信息管理系统(His)中提取该院2012年1月-2015年12月头孢他啶消耗数量(1.0g)及对应年度大肠杆菌等6种临床常见革兰阴性细菌的分离株和其对头孢他啶的耐药数据,采用SPSS 17.0统计软件进行统计分析。结果:大肠杆菌是该院分离最多的一种革兰阴性细菌,其次为克雷伯菌和鲍曼不动杆菌。2013年至今,鲍曼不动杆菌分离数量呈显著增加的趋势。3种细菌对头孢他啶的耐药率呈逐年降低的趋势;与2014年比较,2015年鲍曼不动杆菌对头孢他啶的耐药率降至75.2%。头孢他啶用药频度与大肠杆菌和鲍曼不动杆菌耐药率均呈正相关(P<0.05)。结论:随着头孢他啶用量减少,革兰阴性细菌耐药率也随之降低;头孢他啶的用药频度与革兰阴性细菌耐药之间存在一定的相关性;临床工作中应合理使用抗菌药物,降低细菌耐药率。
OBJECTIVE: To analyze the correlation between the use of ceftazidime in six hospitals and clinical isolates of six Gram-negative bacteria in a hospital from 2012 to 2015, so as to provide a theoretical basis for the rational application of such antibiotics. Methods: The clinical isolates of ceftazidime consumed (1.0g) from January 2012 to December 2015 and six clinical isolates of Gram-negative bacteria such as Escherichia coli were extracted from hospital information management system (His) Ceftazidime resistance data using SPSS 17.0 statistical software for statistical analysis. Results: Escherichia coli was the most gram-negative bacterium isolated in this hospital, followed by Klebsiella and Acinetobacter baumannii. Since 2013, Acinetobacter baumannii isolates showed a significant increase in the number. The resistance rates of ceftazidime to the three kinds of bacteria tended to decrease year by year. Compared with 2014, the rate of ceftazidime resistant to Acinetobacter baumanni decreased to 75.2% in 2015. The frequency of ceftazidime was positively correlated with the drug resistance rate of Escherichia coli and Acinetobacter baumannii (P <0.05). Conclusions: With the decrease of ceftazidime dosage, the resistance rate of Gram-negative bacteria also decreases. The frequency of ceftazidime has some correlation with gram-negative bacteria resistance. In clinical work, antibiotics should be used reasonably to reduce Bacterial drug resistance.