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近年来共轭亚油酸的研究倍受关注,但其生理活性的作用机制还未得以充分阐明.从其所具备的各种生理活性的角度系统地综述了其可能的几种作用机制:作为抗氧化剂改变生物膜的结构,使其免受伤害;是致癌剂引发阶段的有效阻断剂;作用并激活过氧化物增生因子激活受体,从而调控基因的表达;影响某些细胞分裂素的合成和功能;影响生长激素的分泌;抑制恶性肿瘤细胞的增殖与黏附,恢复肿瘤细胞间的细胞间隙连接通讯功能;影响生物体内花生四烯酸和前列腺素的代谢.
In recent years, the research on conjugated linoleic acid has drawn much attention, but the mechanism of its physiological activity has not been fully elucidated.Some possible mechanisms of action are systematically reviewed from the perspectives of its various physiological activities: Antioxidants alter the structure of the biofilm to protect it from injury; it is an effective blocker of the carcinogenic agent in the priming phase; it acts and activates peroxisome proliferator-activated receptors, thereby regulating gene expression; affecting certain cytokinins Synthesis and function; affect the secretion of growth hormone; inhibit the proliferation and adhesion of malignant tumor cells, restoring the cell-cell gap junctional communication between tumor cells; affecting the metabolism of arachidonic acid and prostaglandin in vivo.