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肝脏与止血功能有极为密切的关系,因肝脏能合成除组织凝血活酶(因子Ⅲ)以及因子XⅢα链以外的所有凝血因子、纤溶因子及纤溶抑制因子,还作为网状内皮系统的重要器官,具有清除组织凝血活酶和被激活的凝血因子和纤溶因子的功能。近年来,随着止血血栓研究的深入,对肝脏疾病时止血功能异常的了解有了若干进展,本文介绍如下: 肝脏疾病所致止血功能异常(表1)及其意义凝血因子及其抑制因子的异常纤维蛋白原(Fbg):Fbg为肝脏合成的急性反应相蛋白,除急性肝功能衰竭、肝硬
The liver has a very close relationship with hemostatic function because the liver can synthesize all coagulation factors, fibrinolytic factors and fibrinolysis inhibitors other than tissue thromboplastin (factor III) and factor XIII alpha chain, and also serves as an important reticuloendothelial system Organ, with the function of clearing tissue thromboplastin and activated coagulation factors and fibrinolytic factors. In recent years, with the deepening of the study of hemostatic thrombosis, the understanding of the hemostatic dysfunction in liver disease has made some progress, this article describes the following: hemostatic dysfunction caused by liver disease (Table 1) and its significance clotting factor and its inhibitory factor Abnormal Fibrinogen (Fbg): Fbg is an acute reaction phase protein synthesized by the liver, in addition to acute liver failure, cirrhosis