关于矽尘可促进肺癌发生的问题至今仍有争论。为阐明这个问题,作者用225只非纯种大鼠气管内注入不同含量的3,4-苯并芘混悬液。实验分四组:第1组(58只),同时注入5 mg与50 mg石英粉尘的混合物;第2组(70只),先注入50 mg石英粉尘,经4个月后再注入5 mg;第3组(28只),只注入5 mg;第4组(69只),对照组。实验中所使用的石英粉尘为高分散度的粉尘、粒子直径小于2μm的占82%。实验结果表明:在单纯注入的第3组中,大多数动物可看到肺泡、支气管的弥散性和 The issue of silica dust promoting lung cancer is still debated. To elucidate this problem, the authors used 225 non-purebred rats to intratracheally instillation of different concentrations of 3,4-benzopyrene suspension. In group 1 (58 rats), a mixture of 5 mg and 50 mg of quartz dust was injected simultaneously. In group 2 (70 rats), 50 mg of quartz dust was injected first, followed by 5 mg after 4 months. Group 3 (n = 28) injected only 5 mg; group 4 (n = 69), control group. Quartz dust used in the experiment was a highly dispersed dust with a particle diameter of less than 2 μm accounting for 82%. The experimental results show that: in the simple injection of the third group, most animals can see the alveoli, bronchial disseminated and