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目的探讨胰岛素和口服降糖药物治疗对初诊2型糖尿病(T2DM)患者胰岛β功能影响。方法分别对20例初诊T2DM患者进行为期2周胰岛素强化治疗和口服药物治疗,比较治疗前后空腹血糖(FPG),餐后2h血糖(2hPG),糖化血红蛋白(HbA1c),空腹胰岛素(FIns),及胰岛素分泌指数(HOMA-β),胰岛抵抗指数(HO-MA-IR)。结果胰岛素及口服药物治疗后FPG、2hPG、HbA1c均较治疗前明显下降(P<0·01),FIns、HOMA-β上升(治疗组P<0·01,对照组P<0·05),HOMA-IR下降(P<0·05)。胰岛素治疗组FIns、HOMA-β上升较口服药组明显(P<0·05)。结论胰岛素强化治疗较口服降糖药物显著改善初诊T2DM患者胰岛β细胞功能。
Objective To investigate the effects of insulin and oral hypoglycemic drugs on islet β function in newly diagnosed type 2 diabetes mellitus (T2DM). Methods Twenty patients with newly diagnosed T2DM were treated with 2 weeks of intensive insulin therapy and oral drug treatment. Fasting plasma glucose (FPG), postprandial 2h blood glucose (2hPG), HbA1c, fasting insulin (FIns) Insulin secretion index (HOMA-β), islet resistance index (HO-MA-IR). Results The levels of FPG, 2hPG and HbA1c were significantly decreased (P <0.01), FIns and HOMA-β in treated group (P <0.01 in treatment group and P <0.05 in control group) HOMA-IR decreased (P <0.05). Insulin treatment group FIns, HOMA-β increased significantly (P <0 · 05). CONCLUSION: Compared with oral hypoglycemic agents, intensive insulin therapy significantly improves pancreatic β-cell function in newly diagnosed T2DM patients.