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本文报道一例临床诊断为风湿性心脏病的患者,7次自其血液,1次自其骨髓中分离出两株菌落形态不同的念珠菌,一株具有类星形念珠菌样菌落,另一株菌落不典型。经鉴定两株均为类星形念珠菌(Candida stellatoidea)。对家兔、豚鼠及小鼠作动物接种试验,证明两株均有较弱的致病力。这在国内外为首例报道。本实验结果表明类星形念珠菌像白色念珠菌、热带念珠菌等一样,可作为风湿性心脏病的继发感染菌,引起念珠菌性心内膜炎。临床上应予注意,必要时应采血作真菌学检验,以便作出正确诊断,进行合理治疗。
This article reports a case of clinical diagnosis of rheumatic heart disease patients, seven times since its blood, one from the bone marrow isolated two strains of Candida albicans, one with Candida-like fungus-like colonies, another strain Colonies are not typical. Two strains were identified as Candida albicans (Candida stellatoidea). Inoculation experiments on rabbits, guinea pigs and mice showed that both strains had weaker virulence. This is the first case report at home and abroad. The experimental results show that Candida like Candida albicans, Candida tropicalis, etc., can be used as secondary bacterial infection of rheumatic heart disease, caused by Candida endocarditis. Clinically should be noted, if necessary, blood should be taken for mycological tests in order to make the correct diagnosis, reasonable treatment.