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血管紧张素Ⅱ(AngⅡ)与心交感神经末梢(cSNE)突触前膜的 AT1 受体(AT1 R)结合后,影响交感神经递质去甲肾上腺素(NE)的释放。通过大量的体外、体内动物实验及人心脏组织标本的药物实验,初步认识了 Ang IIⅠ型受体拮抗剂(AT1 RB)作用于突触前膜AT1 R后对NE释放的影响,为临床?
The binding of angiotensin Ⅱ (AngⅡ) to the AT1 receptor (AT1R) on presynaptic membrane of cardiac sympathetic nerve endings (cSNE) affects the release of sympathetic neurotransmitter norepinephrine (NE). Through a large number of in vitro and in vivo animal experiments and human cardiac tissue samples of drug experiments, preliminary understanding of the Ang II type receptor antagonist (AT1RB) on the presynaptic membrane AT1 R on NE release, the clinical?