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目的 探讨脂质过氧化与胎儿窘迫,以及与新生儿缺血缺氧性脑病(HIE)的关系。方法 将产程中发生宫内窘迫的新生儿60例作为研究对象其中出生后无窒息者39例为检测Ⅰ组,有窒息者21例为检测Ⅱ组;取同期正常新生儿30例为对照组。检测各组新生儿脐动脉血超氧化物歧化酶(SOD)、丙二醛水平,观察各组新生儿HIE发生情况;分析宫内窘迫持续不同时间的新生儿SOD、丙二醛的变化及HIE发生情况。结果 (1)SOD水平检测:检测Ⅰ组为(12 896±247)U/gHb,检测Ⅱ组为(9846±268)U/gHb,对照组为(17 282±134)U/gHb。检测Ⅰ、Ⅱ组SOD水平分别与对照组比较,均显著降低,差异有统计学意义(P<0 01)。检测Ⅰ、Ⅱ组共发生HIE9例(HIE组),SOD水平为(7486±245)U/gHb,未发生HIE51例(非HIE组),SOD水平为(13 878±257)U/gHb,两组比较,差异有统计学意义(P<0 01)。检测Ⅰ、Ⅱ组宫内窘迫持续时间≤30min共19例,SOD水平为(17 411±324)U/gHb,持续时间31~120min共26例,SOD水平为(12 076±230)U/gHb,持续时间≥121min共15例,SOD水平为(9786±249)U/gHb。(2)丙二醛水平检测:检测Ⅰ组为(6 3±0 4)μmol/L,检测Ⅱ组为(8 6±1 5)μmol/L,对照组为(4 1±0 5)μmol/L,检测Ⅰ、Ⅱ组丙二醛水平显著高于对照组,两者比较,差异有统计学意义(P<0 01)。HIE组为
Objective To investigate the relationship between lipid peroxidation and fetal distress and neonatal hypoxic-ischemic encephalopathy (HIE). Methods Sixty newborns with intrauterine distress during labor were selected as study objects. Among them, 39 cases were asphyxial after birth, 21 cases were as detection group Ⅱ, and 30 cases with asphyxia were as control group. The levels of superoxide dismutase (SOD) and malondialdehyde (MDA) in neonatal umbilical arteries of each group were measured to observe the occurrence of neonatal HIE in each group. The changes of SOD and malondialdehyde in neonates with intrauterine distress and the HIE What happened? Results (1) The level of SOD was (12 896 ± 247) U / gHb in group Ⅰ, (9846 ± 268) U / gHb in group Ⅱ and (17 282 ± 134) U / gHb in control group. The levels of SOD in group Ⅰ and group Ⅱ were significantly lower than those in control group, respectively (P <0.01). There were 9 cases of HIE (HIE group) and 7486 ± 245 U / g Hb of HIE in group Ⅰ and Ⅱ, there were 51 cases of HIE without HIE and 13 878 ± 257 U / g Hb of SOD The difference was statistically significant (P <0.01). Twenty-nine cases with intrauterine distress lasting less than 30 min in group Ⅰ and group Ⅱ, and the level of SOD was (17 411 ± 324) U / gHb in duration of 31 to 120 min and the level of SOD was (12 076 ± 230) U / gHb , Duration of ≥121min a total of 15 cases, SOD level (9786 ± 249) U / gHb. (2) The level of malondialdehyde was (6 3 ± 0 4) μmol / L in test group Ⅰ, (86 ± 1 5) μmol / L in test group Ⅱ and (4 1 ± 0 5) μmol in test group Ⅱ / L. The level of malonaldehyde in group I and group II was significantly higher than that in control group, the difference was statistically significant (P <0.01). HIE group