目的　探讨血管平滑肌细胞 (VSMC)在糖尿病早期的改变及其与晚期糖化终产物 (AGEs)的关系。　方法　应用荧光分光光度法、免疫组织化学、计算机图像分析和透射电镜等技术 ,研究链脲佐菌素诱导的糖尿病(DM)大鼠血浆和腹主动脉晚期糖化终产物 (AGEs)的含量以及腹主动脉 VSMC的变化。　结果　从 4周起 ,DM大鼠血浆和腹主动脉的 AGEs显著增多 ;腹主动脉 α- SM-肌动蛋白的相对面积减小 ,VSMC的细胞核密度增大 ,线粒体和粗面内质网增多。DM大鼠腹主动脉血小板源生长因子 - A的免疫组织化学反应呈持续阳性。非酶糖化抑制剂氨基胍不降低血糖 ,但能降低血浆和组织的 AGEs水平 ,对 VSMC的改变也有减缓作用。　结论　 VSMC在糖尿病早期已出现由收缩型向合成型转化的趋势 ,AGEs是 VSMC发生改变的重要因素 Objective To investigate the changes of vascular smooth muscle cells (VSMC) in the early stage of diabetes and its relationship with advanced glycation end products (AGEs). Methods Fluorescence spectrophotometry, immunohistochemistry, computer image analysis and transmission electron microscopy were used to investigate the contents of plasma and advanced glycosylation end products (AGEs) in streptozotocin-induced diabetic rats and abdominal Aortic VSMC changes. Results From the 4th week on, the AGEs in plasma and abdominal aorta of DM rats increased significantly. The relative area of ​​α-SM-actin in abdominal aorta decreased, the density of nuclei in VSMC increased, and the number of mitochondria and rough endoplasmic reticulum increased . The immunohistochemistry of platelet - derived growth factor - A in abdominal aorta of DM rats was continuously positive. Aminoguanidine, a non-enzymatic glycation inhibitor, does not lower blood glucose, but can lower AGEs levels in plasma and tissue, and also has a slowing effect on changes in VSMC. Conclusion VSMC has been transformed from contractile to synthetic in the early stage of diabetes, and AGEs are the important factors in the change of VSMC