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目的研究玻璃遮挡日光对大鼠血清骨碱性磷酸酶(bone alkaline phosphatase,BALP)与25-羟维生素D[25-hydroxyvitamin D,25(OH)D]水平的影响,探讨室内日光照射与维生素D代谢的关系。方法2006年9月至11月选用21日龄Wistar大鼠36只,随机分为直接日光照射组、双层玻璃遮挡日光照射组和避光组。3组均喂食维生素D缺乏饲料,实验期60d。每日测量日光中紫外线强度及经玻璃遮挡后紫外线强度,观察3组大鼠血清BALP和25(OH)D水平的差异。结果(1)由于日晒条件不同,紫外线暴露程度差异很大:双层玻璃遮挡后的紫外线强度削减了85.1%;(2)血清BALP日光照射组为(37.79±3.11)U/L,玻璃遮挡组为(36.44±2.95)U/L,避光组为(51.82±7.62)U/L;日光照射组略高于玻璃遮挡组,差异无统计学意义(P>0.05),但两组均显著低于避光组,差异有统计学意义(P<0.05);(3)25(OH)D日光照射组为(13.06±4.07)nmol/L,玻璃遮挡组为(11.14±5.49)nmol/L,避光组为(4.91±4.66)nmol/L;日光照射组高于玻璃遮挡组,差异无统计学意义(P>0.05);两组均显著高于避光组,差异有统计学意义(P<0.05)。结论在暴露时间足够长的情况下,隔着玻璃进行日光浴可以达到与直接日光暴露相似的效果。
Objective To investigate the effects of glass-sheltered sunlight on the serum levels of bone alkaline phosphatase (BALP) and 25-hydroxyvitamin D (25-hydroxyvitamin D, 25 (OH) D] Metabolic relationship. Methods Thirty - six Wistar rats of 21 days old were selected from September to November of 2006 and were randomly divided into direct sunlight group and double - layer glass shade sun light group and dark light group. 3 groups were fed vitamin D deficiency feed, the experimental period 60d. Daily measurements of ultraviolet light intensity and ultraviolet light intensity after the glass shade, observed the differences of serum BALP and 25 (OH) D levels in three groups of rats. Results (1) Due to the different sun exposure conditions, the degree of UV exposure varied greatly: the UV intensity after double-glazing was cut by 85.1%; (2) the serum BALP group was (37.79 ± 3.11) U / (36.44 ± 2.95) U / L in the darkness group and (51.82 ± 7.62) U / L in the darkness group, respectively; there was no significant difference between the shaded group and the shaded group (P> 0.05) (13.06 ± 4.07) nmol / L in the group of 25 (OH) D sunlight and (11.14 ± 5.49) nmol / L in the glass block group, respectively (P <0.05) (4.91 ± 4.66) nmol / L in the darkness group, and higher in the sunlight group than in the glass shade group (P> 0.05). There was a significant difference between the two groups P <0.05). Conclusion Sunblocking through glass can achieve similar effects as direct sunlight exposure when the exposure time is long enough.