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目的:探讨头孢曲松过敏反应的流行病学特点。方法:通过检索1998年1月～2008年6月国内公开发表的有关头孢曲松过敏反应文献报道个案137例,并进行数理统计及分析。结果:头孢曲松过敏反应病例涉及多个器官和(或)系统,前几位分别是皮肤及其附件损害,全身性损害,呼吸系统损害和胃肠系统损害等。全身性损害中又以过敏性休克多见,死亡11例,占总过敏反应的46.97%。发生休克与非休克性过敏反应患者剂量间没有显著性差异。结论:应警惕头孢曲松导致的过敏性休克,大剂量长疗程使用时,应对患者及时进行血液分析及肾功能检测。
Objective: To investigate the epidemiological characteristics of ceftriaxone allergy. Methods: A total of 137 domestic cases of ceftriaxone allergy reported in the literature published from January 1998 to June 2008 were retrieved and analyzed by mathematical statistics. Results: The cases of ceftriaxone allergy involved multiple organs and / or systems. The first few were skin and its accessory damage, generalized injury, respiratory system damage and gastrointestinal system damage respectively. Systemic damage and more common in anaphylactic shock, 11 patients died, accounting for 46.97% of the total allergic reaction. There was no significant difference between the doses of shock and non-shock allergic patients. Conclusions: Anaphylactic shock caused by ceftriaxone should be warned. In case of using large dose and long course of treatment, patients should be tested for blood analysis and renal function timely.