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目的 观察高强度聚焦超声 (highintensityfocusedultrasound ,HIFU)辐照后兔腹主动脉粥样硬化(atherosclerosis ,AS)血管的病理学变化。方法 通过大体、光镜和透射电镜观察HIFU辐照后不同时间 ,兔腹主动脉AS血管的病理学变化。结果 48只兔 (AS组 :n1=2 4,对照组 :n2 =2 4) ,HIFU辐照后腹主动脉出现一定程度损伤 ,但无血管栓塞和破裂 ;辐照后 5d、10d血管损伤呈逐渐恢复趋势 ,对照组恢复更好。结论 HIFU辐照导致兔腹主动脉粥样硬化血管产生可逆性损伤
Objective To observe the pathological changes of atherosclerosis (AS) blood vessels in rabbits after irradiation with high intensity focused ultrasound (HIFU). Methods The pathological changes of the blood vessels in the abdominal aorta of rabbits were observed by light microscopy and transmission electron microscopy at different time points after HIFU irradiation. Results 48 rabbits (AS group: n1 = 24, control group: n2 = 24) showed some damage to the abdominal aorta after HIFU irradiation but no vascular embolism and rupture. Vascular damage occurred on the 5th and 10th day after irradiation Gradual recovery trend, control group recovery better. Conclusion HIFU irradiation can cause reversible injury of atherosclerotic vessels in the abdominal aorta of rabbits