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采用HPLC测定人血浆和尿标本中扑热息痛浓度的方法学研究表明,该法分离度、灵敏度、精密度和线性关系均良好,适用于药代动力学研究。正常人口服两片氨酚待因的扑热息痛药代动力学符合二室开放式模型;动力学方程为C_t=12.74e~(-0.2760~(t-t_L)) +106.39e~(-1.6201~(t-t_L))—119.08e~(-2.9125~(t-t_L))。口服后扑热息痛吸收较快,达峰浓度时间为0.78±0.32小时(0.43—1.31小时)。峰血浆浓度为18.04±7.71mg/1(12.86—31.73mg/l)。消除半衰期为2.62±0.61小时(1.90—3.54小时)。给药后24小时尿中排出的原型扑热息痛为给药剂量的3.3%。肾清除率和非肾清除率分别为0.59±0.19L/h(0.37—0.87L/h)和17.97±3.81L/h(13.45—21.99L/h)。
The methodological study on the determination of paracetamol in human plasma and urine samples by HPLC showed that the method has good resolution, sensitivity, precision and linearity and is suitable for pharmacokinetic studies. The pharmacokinetics of paracetamol administered orally with two tablets of paracetamol in normal subjects accorded with the two-compartment open model. The kinetic equation was Ct = 12.74e ~ (-0.2760 ~ (t-t_L)) + 106.39e ~ (-1.6201 ~ t-t_L)) - 119.08e ~ (-2.9125 ~ (t-t_L)). Paracetamol absorbed faster after oral administration, peak concentration time was 0.78 ± 0.32 hours (0.43-1.31 hours). Peak plasma concentration was 18.04 ± 7.71 mg / 1 (12.86-31.73 mg / l). The elimination half-life was 2.62 ± 0.61 hours (1.90-3.54 hours). The prototype paracetamol excreted in urine 24 hours after dosing was 3.3% of the dose administered. Kidney clearance and non-kidney clearance were 0.59 ± 0.19 L / h (0.37-0.87 L / h) and 17.97 ± 3.81 L / h (13.45-21.99 L / h), respectively.