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目的分析ER+/PR+、ER+/PR-乳腺癌的临床病理特征及预后。方法2000年1月-2005年6月共收治可手术乳腺癌495例,收集临床病理资料,比较162例ER+/PR+乳腺癌和75例ER+/PR-乳腺癌的临床病理特征及预后。率的比较用卡方检验,无瘤生存率用Kaplan-Merie法计算,生存曲线比较用Log-rank检验。结果ER+/PR-组的腋窝淋巴结阳性率高于ER+/PR+组(54.7%vs40.7%),差异有统计学意义(P<0.05),ER+/PR-组中Her-2的表达率高于ER+/PR+组(48.0%vs33.3%),差异有统计学意义(P<0.05)。在其他临床病理特征上两组乳腺癌差异无统计学意义(P>0.05),ER+/PR+的5年无瘤生存率高于ER+/PR-组(89.5%vs82.7%),差异有统计学意义(P<0.05)。结论ER+/PR-组比ER+/PR+组易发生腋窝淋巴结转移且伴有Her-2的表达,ER+/PR+组预后比ER+/PR-组好。
Objective To analyze the clinicopathological features and prognosis of ER + / PR +, ER + / PR- breast cancer. Methods From January 2000 to June 2005, 495 cases of operable breast cancer were treated. The clinical and pathological data were collected. The clinicopathological features and prognosis of 162 breast cancer patients with ER + / PR + and 75 breast cancer patients with ER + / PR-breast cancer were compared. Chi-square test was used to compare the rate of tumor-free survival with Kaplan-Merie method, survival curves were compared by Log-rank test. Results The positive rate of axillary lymph node in ER + / PR- group was significantly higher than that in ER + / PR + group (54.7% vs 40.7%, P <0.05), and the expression of Her-2 in ER + / PR- In ER + / PR + group (48.0% vs33.3%), the difference was statistically significant (P <0.05). There was no significant difference in other clinicopathological features between the two groups (P> 0.05). The 5-year tumor-free survival rate of ER + / PR + group was higher than that of ER + / PR- group (89.5% vs82.7%) Significance (P <0.05). Conclusions Axillary lymph node metastasis and Her-2 expression are more likely to occur in ER + / PR- group than in ER + / PR + group. The prognosis of ER + / PR + group is better than that of ER + / PR- group.