作者们用豚鼠实验研究高脂血症的内耳病理生理变化。取豚鼠40只,投与含胆固醇50%、胆汁0.5%、牛脂肪15%的固体饲料。30天后,开胸从左心室取血用作血清生物化学分析,其后断头取颞骨,制片在光镜和电镜下检查。在实验过程中,观察其一般状态和听力变化,豚鼠表现有体重减轻、全身脱毛,40只中有21只死亡;食 The authors used guinea pig experiments to study the pathophysiological changes of the inner ear of hyperlipidemia. Forty guinea pigs were given solid feed containing 50% cholesterol, 0.5% bile and 15% beef fat. Thirty days later, blood was drawn from the left ventricle on a thoracotomy for biochemical analysis of the serum, followed by decapitation of the temporal bone. The preparation was examined under light and electron microscopy. During the experiment, the general state and hearing changes were observed. Guinea pigs showed weight loss and systemic hair loss, and 21 of 40 died