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体外用吡喹酮药液处理后的日本血吸虫鲜卵进行环卵沉淀试验(COPT)。0.01μg/ml以下浓度药液不能抑制COPT;0.1ug/ml处理60min,1μg/ml处理30min的虫卵,其COPT环沉率及反应强度显著降低。药液浓度与环沉率及反应强度呈负相关。
Fresh eggs of Schistosoma japonicum treated with praziquantel in vitro were subjected to the egg ring precipitation test (COPT). The concentration of 0.01μg / ml could not inhibit the COPT; 0.1μg / ml for 60min, 1μg / ml for 30min of the eggs, the COPT rate of ring deposition and the reaction intensity was significantly reduced. Liquid concentration and the reaction rate was negatively correlated.