奥沙利铂已经越来越多地应用于肿瘤的治疗,它属于三代铂制剂,抗癌谱广,疗效可靠,主要作用机制为通过与DNA形成加合物抑制细胞增殖,体内外试验显示对多种肿瘤细胞株有抑制作用,包括对顺铂和卡铂耐药的细胞株。对胃癌、大肠癌、肝癌、卵巢癌、淋巴瘤、非小细胞肺癌等均有较好的效果,也经历了多中心临床观察。但奥沙利铂的剂量相关性周围神经毒性影响了其临床应用和推广[1]。近年,国内外学者 Oxaliplatin has been increasingly used in the treatment of cancer. It belongs to the third generation of platinum preparation. It has wide anti-cancer spectrum and reliable curative effect. The main mechanism of action is inhibiting the cell proliferation by forming adduct with DNA. A variety of tumor cell lines have inhibitory effects, including cisplatin and carboplatin resistant cell lines. On gastric cancer, colorectal cancer, liver cancer, ovarian cancer, lymphoma, non-small cell lung cancer have a good effect, also underwent a multicenter clinical observation. However, the dose-related peripheral neurotoxicity of oxaliplatin affects its clinical application and promotion [1]. In recent years, domestic and foreign scholars