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目的探讨2型糖尿病(T2DM)的经冠状动脉造影初诊冠心病患者的临床特征。方法回顾性分析2006年1月至2007年5月期间1 358例连续入院并行冠脉造影的T2DM患者的临床资料,按是否合并冠心病分成两组,比较两组患者间的一般情况、各项生化和炎症指标间的差异。结果单因素分析表明两组问年龄、性别、BMI、糖尿病病程、吸烟、HDL-C、FPG、糖化血红蛋白(HbA_1c)存在统计学差异。多因素logistic回归分析确定年龄(OR 1.032;P=0.011)、性别(OR 1.928;P=0.010)、糖尿病病程(OR 1.066;P=0.012)、HbA_1c(OR 1.210;P=0.012)为糖尿病患者发生冠心病的独立危险因素。结论 T2DM患者冠心病的形成与进展可能为多因素共同参与的结果。年龄、性别、糖尿病病程和HbA_1c水平在此过程中可能发挥重要作用。
Objective To investigate the clinical features of newly diagnosed patients with coronary heart disease (T2DM) undergoing coronary angiography. Methods The clinical data of 1 358 consecutive T2DM patients undergoing coronary angiography between January 2006 and May 2007 were retrospectively analyzed. The patients with T2DM were divided into two groups according to whether they were complicated with coronary heart disease or not, and the general conditions between the two groups were compared. Differences between biochemical and inflammatory markers. Results Univariate analysis showed that there were significant differences in age, sex, BMI, duration of diabetes, smoking, HDL-C, FPG and HbA 1c between the two groups. Multivariate logistic regression analysis showed that age (OR 1.032; P = 0.011), gender (OR 1.928; P = 0.010), duration of diabetes (OR 1.066; P = 0.012) and HbA 1c (OR 1.210; Independent risk factors for coronary heart disease. Conclusion The formation and progression of coronary heart disease in T2DM patients may be the result of multiple factors. Age, sex, duration of diabetes and HbA_1c levels may play important roles in this process.