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目的:研究康复新液对复发性口腔溃疡患者血清炎性因子及超氧化物歧化酶(SOD)表达水平的影响。方法:将136例复发性口腔溃疡患者随机分为治疗组和对照组,治疗组使用康复新液治疗,对照组使用复方氯己定含漱液治疗,疗程均为1周;观察比较两组总有效率、3个月内复发率、血清中炎性因子和SOD含量。结果:治疗后治疗组总有效率(91.2%)显著高于对照组(64.7%),差异有统计学意义(P<0.05);两组治疗后比较,治疗组患者溃疡时间及疼痛指数均低于对照组,差异有统计学意义(P<0.05);治疗后比较,治疗组血清中SOD、白介素-2(IL-2)浓度均高于对照组,肿瘤坏死因子-α(TNF-α)及白介素-8(IL-8)水平均低于对照组,差异均有统计学意义(P<0.05)。结论:康复新液治疗复发性口腔溃疡疗效显著,其机制可能与抑制炎性反应、氧化应激有关。
Objective: To study the effects of Kangfuxin solution on serum inflammatory factors and the expression of superoxide dismutase (SOD) in patients with recurrent oral ulcer. Methods: One hundred and sixty-six patients with recurrent oral ulcer were randomly divided into treatment group and control group. The treatment group was treated with Kangfuxin solution and the control group was treated with compound chlorhexidine gargle. The course of treatment was 1 week. Efficacy, relapse rate within 3 months, serum inflammatory cytokines and SOD content. Results: The total effective rate (91.2%) in treatment group was significantly higher than that in control group (64.7%), the difference was statistically significant (P <0.05). After treatment, ulcer time and pain index in treatment group were lower In the control group, the difference was statistically significant (P <0.05). After treatment, the levels of serum SOD and IL-2 in the treatment group were significantly higher than those in the control group. The levels of tumor necrosis factor-α (TNF- And interleukin-8 (IL-8) levels were lower than the control group, the difference was statistically significant (P <0.05). Conclusion: Kangfuxin solution is effective in treating recurrent oral ulcer. Its mechanism may be related to inhibiting inflammatory reaction and oxidative stress.