在ｐＨ８．５～９．５的水溶液中，采用氯化亚锡还原法制备９９Ｔｃｍ－ＣＡＣＰＰＡ，ＴＬＣ和ＨＰＬＣ检测其标记率和放化纯均大于９０％。小鼠体内分布表明，心肌最高摄取率为１８．１７±２．６７％ＩＤ／ｇ；小鼠血药动力学研究表明９９Ｔｃｍ－ＣＡＣＰＰＡ的血液清除快，Ｔ１／２α为１．１１ｍｉｎ，Ｔ１／２β为２０．０８ｍｉｎ，清除速率为０．４０７ｍＬ／ｍｉｎ。９９Ｔｃｍ－ＣＡＣＰＰＡ的体内外血浆蛋白结合率高，ｐＨ７．００和ｐＨ７．４０时分配系数分别为１０．９８和１１．４５；代谢干预研究结果表明，葡萄糖胰岛素组心肌摄取升高，与对照组相比，差异具有显著性意义。 The 99Tcm-CACPPA was prepared by stannous chloride reduction in aqueous solution at pH 8.5 ~ 9.5. The labeling and radiochemical purity of 99Tcm-CACPPA were both over 90% by TLC and HPLC. In vivo distribution in mice showed that the highest uptake rate of myocardium was 18.17 ± 2.67% ID / g. The hemodynamic studies showed that 99Tcm-CACPPA had a fast blood clearance, T1 / 2α was 1.11min, T1 / 2β For 20.08 min with a clearance rate of 0.407 mL / min. 99Tcm-CACPPA in vitro and in vivo plasma protein binding rate, pH7.00 and pH7.40 when the distribution coefficients were 10.98 and 11.45; metabolic intervention study showed that glucose insulin group increased myocardial uptake, and the control group phase Than the difference was significant.