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充血性心力衰竭伴低排出量时的体循环阻力升高可能系由肾素-血管紧张素系统的激动所致,后者的抑制或减弱可降低体循环阻力和改善左室功能.巯甲丙脯氨酸(Captopril)是一种血管紧张素转换酶抑制剂.口服巯甲丙脯氨酸25毫克后体循环阻力显著降低(-41%),心排出量和每次心搏量明显增加(+30%,+49%),心率和平均动脉压降低(-14%,-23%),左室心搏工作指数增加(+26%),多数病人肺毛细血管楔嵌压、右房和肺动脉压、肺血管阻力以及左室充盈压显著下降.服用50毫克和100毫克的血流动
Increased systemic resistance to congestive heart failure with low excretion may result from the activation of the renin-angiotensin system, which may be associated with decreased or decreased systemic resistance and improved left ventricular function. Captopril, an angiotensin-converting enzyme inhibitor, showed a significant reduction in systemic resistance (-41%) and a significant increase in cardiac output and stroke volume (+ 30%) after 25 mg of oral captopril, , +49%), reduced heart rate and mean arterial pressure (-14%, -23%), increased left ventricular cardiac work index (+26%), pulmonary capillary wedge pressure, right atrium and pulmonary artery pressure, Pulmonary vascular resistance and left ventricular filling pressure decreased significantly. Taking 50 mg and 100 mg of blood flow