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目的观察0.15%罗哌卡因加用0.002%芬太尼硬膜外自控镇痛应用于分娩的有效性和安全性。方法选择足月妊娠、头位、单胎、无明显头盆不称且自愿要求分娩镇痛的初产妇60例为观察组,药物为0.15%罗哌卡因加0.002%芬太尼混合液,经微量泵持续硬膜外自控给药。以同期的头位、单胎、无明显头盆不称的初产妇60例作对照组,产程中适当应用地西泮镇静。观察2组分娩产程、子宫收缩及母婴的影响。结果与对照组比较观察组产痛明显减轻(P<0.05);且两组运动阻滞差异无统计学意义(P>0.05)均可下地自如活动;两组各产程、新生儿Apgar评分及阴道流血比较差异无统计学意义(P>0.05);两组分娩方式及宫缩素使用的比较差异无统计学意义(P>0.05)。结论0.15%罗哌卡因加用0.002%芬太尼持续硬膜外自控分娩镇痛安全、有效。
Objective To observe the effectiveness and safety of 0.15% ropivacaine combined with 0.002% fentanyl controlled epidural analgesia for delivery. Methods: Full-term pregnancy, head position, single fetus, primiparous with no obvious head basin and voluntary labor analgesia were selected as observation group. The drug was 0.15% ropivacaine plus 0.002% fentanyl mixture, Continuous micro-pump continuous epidural administration. In the same period of the first position, single births, no obvious primordial primipara 60 cases as control group, appropriate diazepam sedation during labor. The effects of labor, uterine contractions and maternal-infant effects on 2 groups were observed. Results Compared with the control group, the pain in the observation group was significantly relieved (P <0.05). There was no significant difference in the motor block between the two groups (P> 0.05) There was no significant difference in bleeding between the two groups (P> 0.05). There was no significant difference in the mode of delivery and the application of orifixibles between the two groups (P> 0.05). Conclusion 0.15% ropivacaine plus 0.002% fentanyl is safe and effective for continuous epidural analgesia.