The kinetic sstudy of pyrite oxidation was performed in a series of experiments by a mixed flow reactor. The release rates of Fe(II) are in the order of 3.22×10?9-5.51×10?7 mol·m?2·s?1 at temperature (T ) 25 to 44℃, initial pH (pH )1.4 to 2.7, and initial Fe(III) concen-tration ([Fe(III)]i) 10?5 to 5×10?3 mol·kg?1. The release rate of Fe(II) increased with increasing T or/and pH or/and [Fe(III)]i in the above range. The rate law and activation energy of pyrite oxida-tion were derived by statistical analyses of RFe(II) vs. [Fe(III)]i, RFe(II) vs. pH and RFe(II) vs. T, and are given as (1) Rate law: RFe(II) 4.65 64.54 103 8.310.600.4510 e[Fe(III)][H ]? ×Ti= +; (2) activation energy: 64.54 ± 8.07 kJ·mol?1. The expression can be applied to more cases (e.g., quantifying the pollutant re-leased from sulfide-rich mining waste and assessing reliable performance of underground re-pository sites where pyrite acts as an engineered barrier material). Using the rate law derived from this study, the magnitude of the pollutants transferred to secondary phases, soil and water from oxidized pyrite during Jiguanshan mine waste weathering was preliminarily estimated. The estimated magnitude is very high, suggesting that the pile has possibly posed significant impact on the water quality in this region. The kinetic sstudy of pyrite oxidation was performed in a series of experiments by a mixed flow reactor. The release rates of Fe (II) are in the order of 3.22 × 10 -9-5.51 × 10 -7 mol · m -2 · s 1 at a temperature of 25 to 44 ° C., an initial pH of 1.4 to 2.7, and initial Fe (III) concen- tration ([Fe (III)] i) 10 -5 to 5 × 10 -3 mol · kg · 1. The rate of Fe (II) increased with increasing T or / and pH or / and [Fe (III)] i in the above range. The rate law and activation energy of pyrite oxida- tion were derived by statistical RFe (II) vs. pH and RFe (II) vs. T, and given as (1) Rate law: RFe (II) 4.65 64.54 103 8.310 .600.4510 e [Fe (III)] [H] × Ti = +; (2) activation energy: 64.54 ± 8.07 kJ · mol -1. The expression can be applied to more cases (eg, quantifying the pollutant re-leased from sulfide-rich mining waste and assessing reliable performance of underground re-pository sites where pyrite acts as an engineered barrier material). Using the rate law derived from this study, the magnitude of the pollutants transferred to secondary phases, soil and water from oxidized pyrite during Jiguanshan mine waste weathering was preliminarily estimated. The estimated magnitude is very high, suggesting that the pile has possibly posed significant impact on the water quality in this region .