论文部分内容阅读
应用免疫组化检测８８例肝细胞癌（ＨＣＣ）中ｎｍ２３－Ｈ１蛋白的表达。癌旁肝组织强阳性表达，５１例肝癌组织阳性表达（５８％）。阳性产物主要定位于肿瘤细胞胞浆。ｎｍ２３－Ｈ１蛋白表达与ＨＣＣ肿瘤体积，组织分型及Ｅｄｍｏｎｄｓｏｎ分级无关，而与肝内或肝外转移显著负相关。结果表明ｎｍ２３－Ｈ１在抑制ＨＣＣ肝内或肝外转移中起着重要作用，有可能成为评价ＨＣＣ病人预后的一项新指标。
The expression of nm23-H1 protein in 88 cases of hepatocellular carcinoma (HCC) was detected by immunohistochemistry. Strong positive expression of para-carcinoma liver tissue, positive expression of liver cancer in 51 cases (58%). The positive product is mainly located in the cytoplasm of tumor cells. The nm23-H1 protein expression was not associated with HCC tumor volume, histological type and Edmondson grade, but was negatively correlated with intrahepatic or extrahepatic metastasis. The results indicate that nm23-H1 plays an important role in inhibiting intrahepatic or extrahepatic metastasis of HCC and may become a new indicator for evaluating the prognosis of HCC patients.