采用圆二色谱、膜表面电荷及膜流动性指标测定了铁缺乏和运动大鼠红细胞膜的损伤变化。发现铁缺乏和运动两因素同时存在时红细胞膜蛋白的α－螺旋含量显著偏高，边缘缺铁运动组偏低。运动使红细胞膜表面电荷显著下降。反映膜脂质流动性的，值各实验组差异不显著。提示缺铁和运动所致膜损伤与膜蛋白氧化修饰或膜蛋白成分增减有关。 The changes of erythrocyte membrane damage in iron deficiency and exercise rats were measured by circular dichroism, membrane surface charge and membrane fluidity index. Found that iron deficiency and exercise two factors simultaneously erythrocyte membrane protein α-helix content was significantly higher, the edge of the iron deficiency exercise group is low. Exercise significantly decreased the surface charge of the erythrocyte membrane. Reflect the membrane lipid mobility, the value of each experimental group was not significant. Tip iron deficiency and exercise-induced membrane damage and membrane protein oxidation or membrane protein composition changes.