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目的评价早期加用1,6-二磷酸果糖(FDP)对新生儿缺血缺氧性脑病(HIE)的临床干预效果。方法2006年1月至2008年3月四川省眉山市第二人民医院收治的82例中重度HIE患儿随机分为对照组(38例)和治疗组(44例)。对照组常规对症支持治疗,治疗组在常规治疗的基础上加用FDP150mg/(kg.d),连续使用7d。观察患儿的意识状态、肌张力、前囟张力、原始反射等临床指标的变化。结果治疗组HIE患儿临床症状的改善时限较对照组短,治疗组的有效率高于对照组。结论HIE早期加用FDP可获得较常规治疗更好的治疗效果。
Objective To evaluate the effect of early intervention with fructose-1,6-diphosphate (FDP) on neonatal hypoxic-ischemic encephalopathy (HIE). Methods From January 2006 to March 2008, 82 patients with moderate-severe HIE admitted to Second People’s Hospital of Meishan City, Sichuan Province were randomly divided into control group (38 cases) and treatment group (44 cases). Control group conventional symptomatic supportive treatment, the treatment group based on conventional treatment plus FDP150mg / (kg.d), continuous use of 7d. Observation of children’s consciousness, muscle tone, anterior fontanelle, the original reflex and other clinical indicators of change. Results The improvement of clinical symptoms in HIE children in the treatment group was shorter than that in the control group, and the effective rate in the treatment group was higher than that in the control group. Conclusions The use of FDP in the early stage of HIE can achieve better therapeutic effect than conventional treatment.