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目的探讨头痛宁胶囊联合氟桂利嗪胶囊治疗偏头痛的临床疗效。方法选取2015年2月—2016年2月北京市仁和医院收治的偏头痛患者78例,根据治疗药物不同分为观察组与对照组,各39例。对照组给予氟桂利嗪胶囊治疗,观察组在对照组基础上加用头痛宁胶囊治疗。比较两组患者临床疗效、视觉模拟评分法(VAS)评分、血中降钙素基因相关肽(CGRP)、5-羟色胺(5-HT)水平及不良反应发生率。结果观察组总有效率高于对照组,差异有统计学意义(P<0.05)。治疗前两组患者VAS评分、5-HT及CGRP水平比较,差异无统计学意义(P>0.05);治疗后观察组VAS评分、CGRP水平及不良反应发生率低于对照组,5-HT水平高于对照组,差异有统计学意义(P<0.05)。结论头痛宁胶囊联合氟桂利嗪胶囊治疗偏头痛疗效优良,安全性高。
Objective To study the clinical effect of Touttongning capsule combined with flunarizine capsule in the treatment of migraine. Methods 78 patients with migraine who were admitted to Beijing Renhe Hospital from February 2015 to February 2016 were divided into observation group and control group according to different therapeutic drugs, 39 cases in each group. The control group was treated with flunarizine capsules, and the observation group was given Tongtongning capsule on the basis of the control group. The clinical efficacy, visual analogue scale (VAS) score, CGRP, 5-HT levels and the incidence of adverse reactions in both groups were compared. Results The total effective rate in the observation group was higher than that in the control group, with significant difference (P <0.05). There was no significant difference in VAS scores, 5-HT and CGRP levels between the two groups before treatment (P> 0.05). After treatment, the VAS score, CGRP level and the incidence of adverse reactions in the observation group were lower than those in the control group. The 5-HT level Higher than the control group, the difference was statistically significant (P <0.05). Conclusion Touttongning capsule combined with flunarizine capsules for the treatment of migraine has excellent curative effect and high safety.