凝血因素对一些心血管疾病的发生和发展起重要作用,如瓣膜病、心肌病、充血性心力衰竭、心房纤颤及一些心脏手术后容易发生血栓和栓塞,而血凝紊乱,血栓形成更是动脉粥样硬化(简称AS)和冠心病(CHD)发病机理中的重要因素。本文就其在AS和CHD中的作用作一概述。一、AS发生机理的现代概念 AS发生机理的学说甚多,当前多支持综 Coagulation factors play an important role in the occurrence and development of some cardiovascular diseases, such as valvular disease, cardiomyopathy, congestive heart failure, atrial fibrillation and some cardiac surgery prone to thrombosis and embolism, and clotting disorders, thrombosis is more Atherosclerosis (AS) and coronary heart disease (CHD) in the pathogenesis of important factors. This article gives an overview of its role in AS and CHD. First, the modern concept of the mechanism of AS AS many theories of the mechanism of occurrence, the current multi-support comprehensive