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目的系统评价乙型肝炎免疫球蛋白预防乙型肝炎病毒宫内感染的效果。方法检索1994-2010年间MEDLINE和中国生物医学文献数据库,按照入选标准,选出16个随机对照临床试验纳入本研究。用RevMan 3.1软件对其进行统计分析。结果新生儿出生后在免疫接种前抽外周血测乙型肝炎病毒表面抗原为观察终点,预防组和对照组合并的相对危险度为0.31,95%可信区间为(0.23,0.36);单纯乙型肝炎病毒表面抗原阳性母亲和乙肝表面抗原、e抗原双阳性母亲的新生儿合并的相对危险度分别是0.28、0.23。结论乙型肝炎免疫球蛋白预防乙型肝炎病毒宫内感染有较明显的作用,尤其是孕妇为乙型肝炎病毒双阳性携带者。
Objective To systematically evaluate the efficacy of hepatitis B immunoglobulin in preventing hepatitis B virus intrauterine infection. Methods MEDLINE and China Biomedical Literature Database were searched from 1994 to 2010. According to the inclusion criteria, 16 randomized controlled clinical trials were selected for inclusion in this study. Use RevMan 3.1 software for statistical analysis. Results After neonatal birth, peripheral blood samples of peripheral blood were collected before immunization as the end point of observation. The relative risk for the combination of prophylaxis group and control group was 0.31, 95% confidence interval (0.23, 0.36); simple B The relative risk of newborn combination of hepatitis B virus surface antigen positive mother and hepatitis B surface antigen and e antigen double positive mother were 0.28 and 0.23, respectively. Conclusion Hepatitis B immunoglobulin has a significant effect on the prevention of hepatitis B virus intrauterine infection, especially in pregnant women with double positive hepatitis B virus carriers.