目的:探讨痰瘀同治方对兔动脉粥样硬化(AS)对氧磷酶活性及炎症因子的影响。方法:将家兔随机分为正常组、模型组、辛伐他汀组、痰瘀同治方5,2.5,1.25 g.kg-1剂量组;采用主动脉球囊拉伤加高脂喂养造模;造模4周开始给药,给药8周。实验结束后,测定各组总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)和低密度脂蛋白胆固醇(LDL-C)水平,血清对氧磷酶-1(PON-1)活性,C反应蛋白(CRP)和白介素-6(IL-6)含量。结果:与模型组比较,辛伐他汀组和痰瘀同治方5 g.kg-1剂量组家兔TC,LDL-C明显降低,痰瘀同治方5,2.5 g.kg-1剂量组PON-1活性较模型组明显升高,痰瘀同治方各剂量组CRP,TNFα-和IL-6水平较模型组明显降低。结论:痰瘀同治方通过调节血脂,抗炎,保护PON-1活性等途径起到抗AS的作用。 Objective: To investigate the effect of Qi Tong Tong Zhi Fang on atherosclerosis (AS) paraoxonase activity and inflammatory factors in rabbits. METHODS: Rabbits were randomly divided into normal group, model group, simvastatin group and Qitongtongzhi group (5, 2.5, 1.25 g.kg-1) groups. Aortic balloon injury was induced by high fat feeding. The model was administered 4 weeks later and administered for 8 weeks. At the end of the experiment, total cholesterol (TC), triglyceride (TG), high-density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol (LDL-C) levels were measured in each group. Serum paraoxonase-1 was measured. (PON-1) activity, C-reactive protein (CRP) and interleukin-6 (IL-6) content. RESULTS: Compared with the model group, TC and LDL-C levels in the rabbits in the simvastatin group and Qitongtongzhi group at the 5 g.kg-1 dose group were significantly lower, and the PON group was 5 and 2.5 g.kg-1 in the Qitongtongzhi group. 1 The activity was significantly higher than that of the model group. Compared with the model group, the levels of CRP, TNFα- and IL-6 were significantly lower in the different dosage groups of Qitong Tongzhi. Conclusion: Qi Tong Tong Zhi has played an anti-AS role by regulating blood lipids, anti-inflammatory and protecting PON-1 activity.