对人类食管癌高、低发区的流行病学调查表明,缺锌可能与人类食管癌发病有一定关系。 动物实验也证明,缺锌可显著加速和提高甲基苄基亚硝胺(MBNA)对大鼠食管肿瘤的诱发。关于缺锌影响癌变过程的机理尚未阐明。我们的研究表明,用接近生理浓度的锌预处理CHO细胞能显著抑制N-甲基-N-硝基-N-亚硝基胍的致突变作用。有人曾观察到缺锌会导致大鼠食管和前胃组织中参于化学致癌物解毒过程的重要酶系谷胱 Epidemiological survey of human esophageal cancer in high and low incidence areas shows that zinc deficiency may have a certain relationship with the incidence of human esophageal cancer. Animal experiments also show that zinc deficiency can significantly accelerate and enhance methylbenzyl nitrosamines (MBNA) induced esophageal tumor in rats. The mechanism of zinc deficiency affecting carcinogenesis has not been elucidated yet. Our study shows that pretreatment of CHO cells with zinc at near physiological concentrations can significantly inhibit the mutagenesis of N-methyl-N-nitro-N-nitrosoguanidine. It has been observed that zinc deficiency will lead to rat esophagus and pre-gastric tissue involved in the process of chemical carcinogens detoxification enzyme system,