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目的观察卡前列甲酯栓预防剖宫产产后出血的效果及副反应。方法选择218例剖宫产产妇随机分为试验组108例和对照组110例,试验组在胎儿娩出后舌下含服卡前列甲酯栓1mg,手术结束后卡前列甲酯栓1mg直肠给药,两组产妇在胎儿娩出后均向子宫肌层注射缩宫素10 IU,静脉滴注缩宫素20 IU,观察两组产后2h及产后24h的出血量。结果产后2h出血量试验组为335.5±123.2m l,对照组为378.6±178m l,两组相比差异有显著性(P<0.05);产后24h出血量试验组为423±283m l,对照组为516±312m l,两组有显著性差异(P<0.001)。总出血量≥700m l共9例,其中试验组1例(0.9%),对照组8例(7.27%)。副反应发生率试验组约7.4%(8例),表现为舌下含服时轻度恶心、呕吐,短时间内消失。结论卡前列甲酯栓在剖宫产术中促进子宫收缩明显,能较好地预防产后出血。
Objective To observe the effect of carbamazepine suppository on prevention of bleeding after cesarean section and its side effects. Methods 218 cases of cesarean section were randomly divided into experimental group of 108 cases and control group of 110 cases, the test group after the child was delivered sublingual card forefront of methyl ester suppository 1mg, after surgery cardinal methylester suppository 1mg rectal administration , Two groups of mothers after injection of the fetus to the myometrium injection of oxytocin 10 IU, intravenous infusion of oxytocin 20 IU, two groups of postpartum 2h and 24h postpartum bleeding. Results The amount of hemorrhage 2 hours after delivery was 335.5 ± 123.2 ml in the test group and 378.6 ± 178 ml in the control group, with a significant difference between the two groups (P <0.05). The amount of hemorrhage 24 hours after delivery was 423 ± 283 ml in the control group 516 ± 312m l, there was a significant difference between the two groups (P <0.001). Total bleeding ≥700m l in a total of 9 cases, of which 1 case (0.9%) in the test group, control group, 8 cases (7.27%). The incidence of side effects in the test group about 7.4% (8 cases), manifested as mild sublingual nausea vomiting, disappear within a short time. Conclusion Cardinal methylester suppository in the cesarean section to promote significant contraction of the uterus, can better prevent postpartum hemorrhage.