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目的分析他汀类药物对血脂及颈动脉斑块的影响。方法回顾性分析2007年1月1日-2014年3月30日我院收治的血脂异常、有颈动脉粥样硬化斑块患者384例。其中采用瑞舒伐他汀治疗45例,采用阿托伐他汀治疗32例,采用普伐他汀治疗63例,采用辛伐他汀治疗9例。未采用他汀药治疗235例。对比5组患者治疗前后三酰甘油(TG)、总胆固醇(TC)、高密度脂蛋白胆固醇C(HDL-C)和低密度脂蛋白胆固醇C(LDL-C)水平,治疗前后颈动脉内中膜厚度(IMT)和劲动脉斑块最大面积。结果 5组治疗前后TG、TC、HDL-C、LDL-C水平差异无统计学意义(P>0.05)。4组他汀类用药患者用药后IMT较治疗前均有增厚趋势,但差异无统计学意义(P>0.05)。对照组治疗前后IMT差异无统计学意义(P>0.05)。4组他汀类用药患者治疗前后斑块面积差异无统计学意义(P>0.05)。对照组治疗后斑块面积较治疗前增大(P<0.05)。结论小剂量他汀药物可能对斑块逆转无作用,但可能有延缓斑块面积增长作用。
Objective To analyze the effect of statins on blood lipid and carotid artery plaque. Methods A retrospective analysis of January 1, 2007 - March 30, 2014 in our hospital for treatment of dyslipidemia, carotid atherosclerotic plaque in 384 patients. Among them, 45 cases were treated with rosuvastatin, 32 cases were treated with atorvastatin, 63 cases were treated with pravastatin and 9 cases were treated with simvastatin. No statin treatment in 235 cases. The levels of triglyceride (TG), total cholesterol (TC), high density lipoprotein cholesterol (HDL-C) and low density lipoprotein cholesterol (LDL-C) in the five groups before and after treatment were compared before and after treatment Film thickness (IMT) and maximum area of the arterial plaque. Results There were no significant differences in TG, TC, HDL-C and LDL-C levels before and after treatment in the 5 groups (P> 0.05). IMT in patients in statin group was thicker than before treatment in four groups, but the difference was not statistically significant (P> 0.05). There was no significant difference in IMT before and after treatment in the control group (P> 0.05). There was no significant difference in plaque area between the four statin groups before and after treatment (P> 0.05). The area of plaque in control group increased compared with that before treatment (P <0.05). Conclusion Small doses of statins may have no effect on plaque reversal, but may have the effect of retarding the plaque area growth.