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目的探究肝部分切除术对伴肝脂肪病变肝癌患者治疗的效果及预后。方法采用回顾性研究方法分析2009年5月至2013年5月收治的230例肝癌患者的临床资料,按照患者是否伴有肝脂肪病变将所有患者分为两组,观察组患者伴肝脂肪病变,共90例,对照组患者不伴肝脂肪病变,共140例,比较两组患者的年龄、BMI值、血清转氨酶水平、胆红素水平、前白蛋白水平以及术后并发症发生率。结果观察组患者总胆红素升高水平、丙氨酸转氨酶升高水平、天冬氨酸转氨酶升高水平以及前白蛋白降低水平均高于对照组(P均<0.01);同时观察组患者术后病死率、肝衰竭发生率以及其他需要临床干预治疗的并发症的发生率均高于对照组(P<0.05或P<0.01)。结论肝脂肪变性会加剧肝切除术后患者肝功能的损伤,导致并发症的发生率增高。
Objective To investigate the effect and prognosis of partial hepatectomy on hepatocellular carcinoma patients with hepatic steatosis. Methods A retrospective study was conducted to analyze the clinical data of 230 patients with HCC who were treated from May 2009 to May 2013. All patients were divided into two groups according to whether the patients had hepatic steatosis or not. The patients in the observation group were accompanied with hepatic steatosis, A total of 90 cases, the control group of patients without hepatic steatosis, a total of 140 cases, the two groups were compared age, BMI, serum aminotransferase levels, bilirubin levels, prealbumin levels and postoperative complications. Results In the observation group, the levels of total bilirubin, elevated alanine aminotransferase, elevated aspartate aminotransferase and pre-albumin were lower in the observation group (all P <0.01) Postoperative mortality, the incidence of liver failure and other complications requiring clinical intervention were significantly higher than those in the control group (P <0.05 or P <0.01). Conclusion Hepatic steatosis may aggravate the liver function damage after hepatectomy, resulting in an increased incidence of complications.