论文部分内容阅读
目的:观察罗哌卡因连续硬膜外阻滞进行分娩镇痛对产妇血清中IL-6、IL-8、IL-10的影响。方法:将200例产妇随机分为观察组和对照组各100例。观察组在宫口开至2～3 cm时,开始采用连续硬膜外阻滞进行分娩镇痛;对照组按产科常规处理。观察两组产妇分娩镇痛前30 min、分娩镇痛后2 h、分娩后24 h、48 h和72 h等5个时点的IL-6、IL-8、IL-10水平的变化。结果:两组产妇分娩镇痛后血清IL-6、IL-8、IL-10水平与分娩镇痛前比较均有升高(P<0.01),且多在分娩后24 h达峰值,对照组较观察组升高更为明显(P<0.05)。结论:罗哌卡因连续硬膜外阻滞进行分娩镇痛可有效降低产妇分娩后炎性应激反应。
Objective: To observe the effects of labor analgesia with continuous epidural block of ropivacaine on serum IL-6, IL-8 and IL-10 in maternal. Methods: 200 maternal women were randomly divided into observation group and control group of 100 cases. The observation group in the cervix to 2 ~ 3 cm, began to use continuous epidural block analgesia; control group according to obstetrical routine treatment. The changes of IL-6, IL-8 and IL-10 in the two groups were observed 30 minutes before labor analgesia, 2 hours after labor analgesia, 24 hours, 48 hours and 72 hours after delivery. Results: The levels of IL-6, IL-8 and IL-10 in the two groups after labor analgesia were significantly higher than those before labor analgesia (P <0.01), and reached the peak at 24 hours after delivery. Compared with the observation group increased more significantly (P <0.05). Conclusion: Continuous epidural blockade of ropivacaine for labor analgesia can effectively reduce the post-partum maternal inflammatory response.