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目的:探讨维持性血液透析患者(MHD)认知功能障碍(CI)与脉压(PP)的相关性。方法:选择透析患者120例,采用蒙特利尔认知评估表(Mo CA)行认知功能评分,将患者分为CI组与非CI组,检测各患者脉压和横断面,调查年龄、性别、受教育年限、并发症、透析龄等临床数据。将两组各数据进行对比分析。结果:68例发生CI,发生率为56.7%;两组患者性别、透析龄比较差异无统计学意义(P>0.05);CI组年龄、脉压明显大于非CI组(P<0.05);CI组受教育年限短于非CI组(P<0.05);CI组高血压、糖尿病、冠心病占37.2%,明显高于非CI组(P<0.05)。68例CI患者中,脉压与Mo CA评分呈负相关(P<0.05);Logistic回归分析显示,年龄、受教育年限、并发症、脉压是MHD患者CI的独立危险因素。结论:脉压在维持性血液透析患者中偏高,且为患者发生认知功能障碍的重要危险因素之一。
Objective: To investigate the correlation between cognitive impairment (CI) and pulse pressure (PP) in maintenance hemodialysis patients (MHD). Methods: One hundred and twenty patients were selected for dialysis. MoCA score was used to divide the patients into two groups: CI group and non-CI group. The pulse pressure and cross-sectional area of each group were measured. Age, gender, Educational years, complications, dialysis age and other clinical data. The two groups of data for comparative analysis. Results: CI occurred in 68 cases with a rate of 56.7%. There was no significant difference in gender and dialysis age between the two groups (P> 0.05). CI and age were significantly higher than those in non-CI group (P <0.05) CI group had 37.2% of hypertension, diabetes and coronary heart disease, which was significantly higher than that of non CI group (P <0.05). Among 68 CI patients, the pulse pressure was negatively correlated with MoCA score (P <0.05). Logistic regression analysis showed that age, educational years, complications and pulse pressure were independent risk factors for CI in MHD patients. Conclusion: Pulse pressure is high in maintenance hemodialysis patients and is one of the important risk factors of cognitive dysfunction in patients.