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目的探讨抵抗素与妊娠生理性胰岛素抵抗(IR)和妊娠糖尿病(GDM)的关系。方法以Westernblot法检测妊娠妇女腹部皮下脂肪组织、胎盘及非妊娠妇女腹部皮下脂肪组织的抵抗素蛋白表达情况。结果胎盘抵抗素蛋白的图像分析表达量[(67905±8441)A]明显高于妊娠[(40718±3818)A]和非妊娠妇女腹部皮下脂肪组织[(38288±2084)A](P<0.01),后两组间差异不明显。结论胎盘所分泌的抵抗素高于脂肪组织;抵抗素可能是引起妊娠生理性IR和GDM的因素之一。
Objective To investigate the relationship between resistin and gestational insulin resistance (IR) and gestational diabetes mellitus (GDM). Methods Western blot was used to detect the resistin protein expression in abdominal subcutaneous adipose tissue, placenta and abdomen subcutaneous adipose tissue of pregnant women. Results The expression level of placental resistin was significantly higher than that of the pregnancy (40718 ± 3818 A) and the subcutaneous adipose tissue of the non-pregnant women (38288 ± 2084 A) (P <0.01) ), After the difference between the two groups is not obvious. Conclusion Placental secreted resistin is higher than adipose tissue; resistin may be one of the factors that cause physiological IR and GDM during pregnancy.