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采用Nab~(TM)技术制备载多西他赛的牛血清白蛋白纳米粒,以粒径、包封率和载药量为指标,基于单因素试验和正交设计对处方进行优化。并采用动态透析法,考察其体外释放特性。结果表明,多西他赛白蛋白纳米粒优化处方为:牛血清白蛋白1%、氯仿/乙醇比11:1、油/水相比例1:49、药载比1:14.8、水相pH 6.6;制备时乳化均质压力为151.68 MPa,均质25次。照上述优化处方和工艺制备的3批样品平均粒径为(190.10-11.91)nn,包封率为(95.6±0.5)%,载药量(8.1±0.1)%,并具有缓释效果。
Preparation of docetaxel-loaded bovine serum albumin nanoparticles by Nab ~ (TM) technology was used to optimize the formulation based on single-factor experiments and orthogonal design with particle size, entrapment efficiency and drug loading. And using dynamic dialysis method to investigate its in vitro release characteristics. The results showed that docetaxel albumin nanoparticle optimized prescription: 1% bovine serum albumin, chloroform / ethanol ratio 11: 1, oil / water ratio 1:49, drug loading ratio 1: 14.8, The homogenization pressure of preparation was 151.68 MPa and 25 times. The average particle size of the three batches prepared according to the optimized formulation and process was (190.10-11.91) nn, the encapsulation efficiency was (95.6 ± 0.5)% and the drug loading was (8.1 ± 0.1)%.