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目的探讨我国四川省凉山彝族人群胰岛素抗药性(IR)与原发性高血压(EH)的关系。方法应用病例对照研究方法,对113例彝族 EH 患者和156例血压正常的彝族对照进行分析,检测空腹血浆葡萄糖(FPG)和胰岛素(FINS)水平,并以 IR 指数作为衡量 IR 的指标。结果彝族移民空腹血糖受损(IFG)、IR 与 EH 的关联均具有统计学意义,OR 值分别为3.98(2.14～7.42,P<0.001)和2.55(1.35～4.83,P=0.004)。按性别分层,彝族男性移民 IFG、IR 与 EH 的关联仍具有统计学意义,OR 值分别为4.31(2.01～9.24,P<0.001)和3.14(1.45～6.82,P=0.003);彝族女性移民 IFG 与 EH 的关联具有统计学意义,OR 值3.46(1.17～10.22,P=0.022),但未发现 IR 与 EH 的关联具有统计学意义。彝族农民 IFG、IR 与 EH 的关联均不具有统计学意义。logistic 回归分析结果显示,彝族移民 IR 与 EH 的关联有统计学意义,但在彝族农民中未观察到这种现象。结论在四川凉山彝族移民中,IR 可能是 EH 发病的危险因素,但在凉山彝族农民中 IR 是否为 EH 发病的危险因素仍有待进一步研究。
Objective To investigate the relationship between insulin resistance (IR) and essential hypertension (EH) in Yi people in Liangshan, Sichuan Province, China. Methods A case-control study was conducted in 113 Yi patients with EH and 156 normal controls. The fasting plasma glucose (FPG) and insulin (FINS) levels were measured. IR index was used as a measure of IR. Results The association between fasting blood glucose (IFG), IR and EH in Yi immigrants was statistically significant (OR = 3.98, 2.14-7.42, P <0.001) and 2.55 (1.35-4.83, P = 0.004). According to sex stratification, the association of IFG, IR and EH in Yi male immigrants was still statistically significant with OR values of 4.31 (2.01 ~ 9.24, P <0.001) and 3.14 (1.45 ~ 6.82, P = 0.003) The correlation between IFG and EH was statistically significant, OR was 3.46 (1.17 ~ 10.22, P = 0.022), but no correlation was found between IR and EH. The association of Yi peasant IFG, IR and EH is not statistically significant. Logistic regression analysis showed that the correlation between IR and EH of Yi immigrants was statistically significant, but this phenomenon was not observed in Yi peasants. Conclusion IR may be a risk factor for EH in Liangshan Yi immigrants in Sichuan Province. However, whether IR is a risk factor for EH in Liangshan Yi peasant remains to be further studied.