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目的探讨血清抗-HBc IgM检测在乙型病毒性肝炎疫情监测中的应用,为提高病例报告准确性,为规范乙肝报告提供科学依据。方法 2013-2015年对五华县“法定传染病报告系统”中报告的乙肝病例中,“HBsAg阳性时间”报告为“既往未检测或结果不详”的病例进行血样采集,进行血清抗-HBc IgM 1∶1 000检测。同时收集2010-2012年乙肝疫情相关数据进行比较分析。结果 2010-2012年五华县乙肝急性、慢性分别占2.08%、96.49%,2013-2015年乙肝急性、慢性分别占11.53%、85.37%,2013-2015年的急性乙肝、慢性乙肝占比与2010-2012年比较,差异均有统计学意义(χ~2=51.23、53.78,均P<0.05);开展血清学抗-HBc IgM 1∶1000检测后,急性乙肝的比例明显上升,慢性乙肝的比例明显下降。结论乙肝的诊断报告需要进一步规范。血清抗-HBc IgM 1∶1 000检测可以提高诊断准确率,规范乙肝疫情报告。
Objective To investigate the application of serum anti-HBc IgM detection in the surveillance of epidemic situation of hepatitis B virus, in order to improve the accuracy of case report and provide a scientific basis for regulating hepatitis B report. Methods From 2013 to 2015, blood samples were collected from cases of hepatitis B reported in Wuhua County’s Notified Disease Reporting System, and HBsAg positive time was reported as not previously known or with unknown results. Serum anti-HBc IgM 1: 1000 assay was performed. At the same time collect the data of 2010-2012 epidemic situation of hepatitis B comparative analysis. Results Acute and chronic hepatitis B in Wuhua County from 2010 to 2012 accounted for 2. 08% and 96.49% respectively. Between 2013 and 2015, acute and chronic hepatitis B accounted for 11.53% and 85.37% respectively. The proportions of acute hepatitis B and chronic hepatitis B in 2013-2015 and 2010 - 2012, the difference was statistically significant (χ ~ 2 = 51.23,53.78, all P <0.05); carry out serological anti-HBc IgM 1: 1000 detection, the proportion of acute hepatitis B increased significantly, the proportion of chronic hepatitis B Significant decline. Conclusion The diagnosis of hepatitis B needs to be further standardized. Serum anti-HBc IgM 1: 1 000 test can improve the diagnostic accuracy, regulate hepatitis B epidemic report.