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目的:探讨奥美拉唑联合奥曲肽治疗小儿上消化道出血的临床效果。方法:该研究选择的对象为2012年6月至2015年4月医院收治的120例上消化道出血的患儿,根据患儿在治疗消化道出血中所采用的药物治疗方案的不同将其分为对照组与治疗组,所有患儿入院之后均禁食禁水,纠正电解质的紊乱,必要的患儿采用输血治疗,同时选择合适的抗生素进行预防感染。对照组患儿在常规治疗的基础上静脉滴注奥美拉唑;治疗组患儿在对照组治疗方案的基础上行奥曲肽治疗,观察的指标为两组患儿上消化道出血的治疗有效率。结果:治疗组患儿显效30例,有效24例,无效6例,治疗有效率为90.0%,显著性的高于对照组患儿的治疗有效率,两组治疗有效率进行比较有统计学意义(P<0.05)。结论:应用奥曲肽联合奥美拉唑的治疗方案与单纯应用奥美拉唑相比能够在短时间内迅速止血,提高临床治疗有效率,值得对该治疗方案进行临床推广应用。
Objective: To investigate the clinical effect of omeprazole combined with octreotide in treating upper gastrointestinal bleeding in children. Methods: The subjects of this study were 120 children with upper gastrointestinal bleeding who were admitted to the hospital from June 2012 to April 2015. According to the drug treatment plan used in children with gastrointestinal bleeding, For the control group and treatment group, all children were fasting water after admission to correct the electrolyte disorders, the necessary treatment of children with transfusion, while selecting the appropriate antibiotics to prevent infection. Children in the control group were given omeprazole intravenously on the basis of routine treatment. The patients in the treatment group were treated with octreotide on the basis of the treatment regimen in the control group. The observed indexes were the treatment effective rate of upper gastrointestinal bleeding in both groups. Results: The treatment group of children markedly effective in 30 cases, effective in 24 cases, 6 cases of ineffective, the effective rate was 90.0%, significantly higher than the control group, the treatment of children with effective rate of treatment was statistically significant (P <0.05). Conclusion: The combination of octreotide and omeprazole can rapidly stop bleeding in a short period of time compared with omeprazole alone, and improve the efficiency of clinical treatment. Therefore, it is worthy of clinical application.