论文部分内容阅读
目的观察甲泼尼龙联合阿奇霉素序贯疗法治疗小儿支原体肺炎的临床疗效,探讨其对血清C反应蛋白(CRP)、可溶性髓系细胞触发受体1(s TREM-1)水平的影响。方法选取2015年1月—2017年1月华中科技大学同济医学院附属武汉儿童医院儿科收治的支原体肺炎患儿120例,根据入院顺序分为对照组和观察组,每组60例。在对症治疗基础上,对照组患儿采用阿奇霉素序贯疗法治疗,观察组患儿采用甲泼尼龙联合阿奇霉素序贯疗法治疗。比较两组患儿临床治疗有效率、症状消失时间、治愈时间及治疗前后血清CRP、s TREM-1水平。结果观察组患儿临床治疗有效率高于对照组(P<0.05)。观察组患儿退热时间、咳嗽消失时间及治愈时间短于对照组(P<0.05)。治疗前两组患儿血清CRP、s TREM-1水平比较,差异无统计学意义(P>0.05);治疗后观察组患儿血清CRP、s TREM-1水平低于对照组(P<0.05);治疗后两组患儿血清CRP、s TREM-1水平均低于治疗前(P<0.05)。结论甲泼尼龙联合阿奇霉素序贯疗法治疗小儿肺炎支原体肺炎的临床疗效确切,可快速有效地改善患儿临床症状并抑制炎性反应,降低血清CRP和s TREM-1水平。
Objective To observe the clinical efficacy of sequential treatment of methylprednisolone combined with azithromycin in treatment of children with mycoplasma pneumonia and explore its effect on serum C-reactive protein (CRP) and soluble myeloid cell trigger receptor 1 (s TREM-1). Methods From January 2015 to January 2017, 120 children with mycoplasma pneumonia admitted to Wuhan Children’s Hospital affiliated to Tongji Medical College of Huazhong University of Science and Technology were divided into control group and observation group according to admission sequence, with 60 cases in each group. On the basis of symptomatic treatment, the control group of children treated with azithromycin sequential therapy, the observation group of children treated with methylprednisolone combined with azithromycin sequential therapy. The clinical efficacy, symptom disappearance time, cure time and serum CRP, s TREM-1 levels in both groups were compared. Results The effective rate of clinical treatment in observation group was higher than that in control group (P <0.05). The observation group patients with fever, cough disappear time and cure time is shorter than the control group (P <0.05). There was no significant difference in serum CRP, s TREM-1 levels between the two groups before treatment (P> 0.05). After treatment, the levels of serum TRP-1 and CRP in the observation group were lower than those in the control group (P <0.05) After treatment, serum levels of CRP and s TREM-1 in both groups were lower than those before treatment (P <0.05). Conclusion The combination of methylprednisolone and azithromycin has the definite curative effect in the treatment of Mycoplasma pneumoniae pneumonia. It can quickly and effectively improve the clinical symptoms, inhibit the inflammatory reaction and decrease the serum levels of CRP and s-TREM-1.