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各种急性与慢性应激时，循环血中及脑、心血管、肾腺等组织中血管紧张素Ⅱ（ＡⅡ）显著增多；人剧烈运动后血浆ＡⅡ与皮质醇一样均剧烈增加，在慢性应激性高血压动物循环及组织中，ＡⅡ含量持续地增高。还发现高浓度ＡⅡ对肾上腺糖皮质激素的分泌有直接的刺激作用，而组织ＡⅡ增多又受肾上腺素能β受体的激发。根据近年来的系列工作，并结合文献，我们认为ＡⅡ是一种重要的应激激素；肾素－血管紧张素系统是一个应激激素反应系统；它与经典的应激激素反应系统，下丘脑－垂体－肾上腺皮质系统及交感－肾上腺髓质系统也存在着密切的关系。
Acute and chronic stress, the circulating blood and brain, cardiovascular, kidney and other tissues of angiotensin Ⅱ (A Ⅱ) increased significantly; after acute exercise, plasma A Ⅱ and cortisol are the same as sharp increase in the chronic In the circulatory and tissue of the animals with irritable hypertension, AⅡconcentration increased continuously. Also found that high concentrations of A Ⅱ adrenal glucocorticoid secretion has a direct stimulating effect, and tissue A Ⅱ increased adrenergic β receptor stimulation. According to a series of work in recent years, combined with the literature, we believe that A Ⅱ is an important stress hormone; renin - angiotensin system is a stress hormone response system; it with the classic stress hormone response system, the hypothalamus - Pituitary - adrenal system and sympathetic - adrenal medulla system there is also a close relationship.