作者首先指出,尽管暴发型肝炎的治疗需要解决许多问题,包括其主要并发症肝昏迷及消化道出血,但最重要的问题应是防止肝细胞坏死的继续进行,促进肝细胞的正常再生以及恢复存余肝细胞至足以维持机体正常内环境的水平。有人报道,暴发型肝炎患者的血清对离体肝细胞的再生呈现致肝毒性和抑制活性。虽认为暴发型肝炎时肝细胞再生的缺失似应归咎于患者血液内的某种体液性物质,但该物质迄今未能检出,而且抑制活性的变化与病理情况的关系及其治疗也都未阐明,因此本文作者就暴发型肝炎患者血清对大鼠原代培养细胞的DNA和蛋白合成的影响及其性 The authors first point out that although the treatment of fulminant hepatitis needs to address a number of issues, including its main complication of hepatic coma and gastrointestinal bleeding, the most important issue should be to prevent the continuation of hepatocellular necrosis and to promote the normal regeneration and recovery of hepatocytes Storing surplus liver cells to maintain the body’s normal internal environment levels. It has been reported that the serum of patients with fulminant hepatitis exhibits hepatotoxicity and inhibitory activity on the regeneration of isolated hepatocytes. Although the absence of hepatocyte regeneration in fulminant hepatitis is thought to be attributable to some body fluid in the patient’s bloodstream, the substance has so far failed to be detected and the relationship between the change in inhibitory activity and the pathological condition and its treatment have not been Therefore, the author of this paper on the impact of patients with fulminant hepatitis serum on rat primary cultured cells DNA and protein synthesis and its impact