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目的探讨雷洛昔芬对膀胱癌RT4细胞增殖和迁移的影响。方法 CCK-8法检测雷洛昔芬对RT4细胞增殖的影响,Transwell法检测雷洛昔芬对RT4细迁移能力的影响。结果与空白对照组相比,雷洛昔芬干预组RT4细胞增殖显著降低(P<0.05),RT4细胞穿膜细胞数目明显减少(P<0.05),成明显剂量依赖性。结论雷洛昔芬能够抑制RT4细胞增殖和迁移能力。
Objective To investigate the effects of raloxifene on the proliferation and migration of bladder cancer RT4 cells. Methods The effects of raloxifene on the proliferation of RT4 cells were detected by CCK-8 assay. The effects of raloxifene on the migration of RT4 cells were detected by Transwell assay. Results Compared with the blank control group, the proliferation of RT4 cells in raloxifene group was significantly decreased (P <0.05), and the number of transmembrane cells in RT4 cells was significantly decreased (P <0.05) in a dose-dependent manner. Conclusion raloxifene can inhibit the proliferation and migration of RT4 cells.