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目的 探讨 p16蛋白与乳腺癌病期及转移的关系。方法 应用 S- P法 ,对 87例乳腺癌 ( ～ 期 )石蜡切片进行免疫组化染色。结果 87例乳腺癌组织中 ,p16表达阳性率为 5 7.5 % (5 0 /87) , 期病人与 、 期病人间p16表达率差异有显著性 (P<0 .0 5 ) ;不同大小肿瘤 ,不同组织学类型 p16表达差异无显著性。 p16表达阳性组与阴性组之间生存曲线差异无显著性。结论 检测 p16蛋白的表达对于了解乳腺癌生物学行为具有重要意义。
Objective To investigate the relationship between the expression of p16 protein and the stage and metastasis of breast cancer. Methods Using S-P method, 87 cases of breast cancer (~ stage) paraffin sections were immunohistochemically stained. Results The positive rate of p16 expression was 87.5% (50/87) in 87 cases of breast cancer. There was a significant difference in the expression of p16 between patients and patients (P <0.05) There was no significant difference in p16 expression between different histological types. There was no significant difference in survival curves between p16 positive group and negative group. Conclusion Detection of p16 protein expression is of great significance for understanding the biological behavior of breast cancer.