论文部分内容阅读
目的探讨对氧磷酶(PON)在冠心病(CHD)患者中的临床意义。方法经选择性冠状动脉造影结果将300例入院患者分为冠心病组240例和对照组60例。冠心病组根据临床诊断分为稳定型心绞痛(SAP)组60例和急性冠脉综合征(ACS)组180例;根据冠脉病变类型分为A型病变、B型病变和C型病变组,血清PON水平通过乙酸苯酯法测定。结果 PON水平明显低于对照组,PON水平明显低于SAP组,随冠状动脉病变类型和冠状动脉病变程度的加重,PON水平逐渐下降。结论 PON是反映冠状动脉粥样硬化斑块局部炎症的较好指标,是决定斑块稳定性的机制之一。
Objective To investigate the clinical significance of paraoxonase (PON) in patients with coronary heart disease (CHD). Methods Selective coronary angiography results were divided into 300 cases of coronary heart disease in 240 patients and control group of 60 patients. According to the clinical diagnosis, coronary heart disease group was divided into stable angina pectoris (SAP) group (60 cases) and acute coronary syndrome group (ACS) group (180 cases). According to the type of coronary artery disease, the patients were divided into type A, type B and type C, Serum PON levels were determined by the phenyl acetate method. Results The level of PON was significantly lower than that of the control group. The PON level was significantly lower than that of the SAP group. The level of PON decreased with the severity of coronary artery disease and coronary artery disease. Conclusion PON is a good indicator to reflect the local inflammation of atherosclerotic plaque and is one of the mechanisms that determine the stability of plaque.