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从一例诊断为低分化鼻咽癌病人的鼻咽部肿物活检组织建立了鼻咽癌上皮细胞株(CNE-2)。初步研究了细胞株的生物学特性和与EB病毒的关系。在病人鼻咽脱落细胞和CNE-2早代细胞中检查出EBNA,但多次传代后EBNA却转为阴性,其原因尚待进一步研究。
A nasopharyngeal epithelial cell line (CNE-2) was established from a biopsy of a nasopharyngeal tumor in a patient diagnosed with poorly differentiated nasopharyngeal carcinoma. The biological characteristics of the cell line and its relationship with Epstein-Barr virus were studied preliminarily. EBNA was detected in patients with nasopharyngeal exfoliated cells and early generation CNE-2 cells, but EBNA was negative after multiple passages. The reasons for this need to be further studied.