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目的:探讨术前动脉灌注化疗在局部晚期乳腺癌治疗中的应用价值。方法:收集我院乳腺外科1998年12月至2000年6月局部晚期乳腺癌患者共26例,采用Seldinger技术置管于乳腺肿瘤的主要供血动脉,灌注化疗药物并行碘油栓塞,2周~4周后行Halsted根治术。观察术前原发癌灶及腋窝淋巴结大小的变化,并对术后标本镜下观察其病理形态变化。结果:23例患者经灌注化疗后,原发癌灶有不同程度的缩小,有效率88.4%;19例有明显的病理学改变,镜下出现不同程度坏死区,组织学有效率79.1%。结论:术前动脉灌注化疗可缩小局部晚期乳腺癌的原发癌灶,减低临床分期,为晚期乳腺癌患者增加手术机会,是抗癌治疗的重要方法之一,值得推广应用。
Objective: To investigate the value of preoperative arterial infusion chemotherapy in the treatment of locally advanced breast cancer. Methods: Totally 26 cases of locally advanced breast cancer from December 1998 to June 2000 in our hospital were treated with Seldinger technique. The main feeding arteries of breast tumors were treated by perfusion of chemotherapeutic drugs and lipiodol embolization for 2 weeks to 4 Week Halsted radical mastectomy. The changes of the size of the primary foci and the axillary lymph nodes before operation were observed. The pathological changes of the specimens were observed under the microscope. Results: Twenty-three patients were treated by perfusion chemotherapy, the primary foci were reduced to varying degrees, the effective rate was 88.4%. Nineteen patients had obvious pathological changes. There were different degrees of necrotic lesions and the histological effective rate was 79.1%. Conclusion: Preoperative arterial infusion chemotherapy can reduce the primary foci of locally advanced breast cancer, reduce the clinical stage, and increase the chance of surgery for patients with advanced breast cancer. Therefore, it is one of the important methods for anticancer treatment and is worth popularizing and applying.